LOXL3 (lysyl oxidase-like 3)

Note LOXL3 is part of the lysyl oxidase (LOX) family, the members of which are secreted extracellular matrix enzymes. LOXL3 contains a C-terminal region that is conserved in all five isoforms of this copper-dependent amine oxidase family. The domains included within this region are a copper-binding site, lysyl and tyrosine residues that form the lysyltyrosine-quinone cofactor (LTQ) and a cytokine receptor-like domain. The Nterminal region of the full-length LOXL3 contains four SRCR (scavenger receptor cysteine-rich) domains that have high levels of homology with the SRCR domains within LOXL2 and LOXL4, but not with the Nterminal part of LOX or LOXL that do not contain SRCR domains.